Short-RInChIKey=SA-FUHFF-UHFFFADPSC-NNQKMYYBCP-UHFFFADPSC-NUHFF-NUHFF-NUHFF-ZZZ

2-(2-Bromophenyl)-N-(tert-butyl)imidazo[1,2-a]pyrazine-3-amine (200 mg, 0.58 mmol, 1.00 equiv), 2-isocyanopropane (60.22 mg, 0.08 mL, 0.87 mmol, 1.5 equiv), potassium acetate (171 mg, 1.74 mmol, 3.00 equiv), Pd- Peppsi (19.8 mg, 0.03 mmol, 0.05 equiv) and XPhos (27.7 mg, 0.06 mmol, 0.10 equiv) were reacted under argon atmosphere in DMF (3 mL) for 18 h at 120 °C. Subsequently, the solvent was removed under reduced pressure.